Improvement in nutrient handling in STZ induced diabetic rats treated with Ocimum gratissimum

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Safety and hypoglycaemic properties of aqueous leaf extract of Ocimum gratissimum in streptozotocin induced diabetic rats.

The claim by Nigerian traditional herbal medicine practitioners that Ocimum gratissimum leaves has antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin and graded doses of the aqueous leaf extract were administered orally to the experimentally diabetic rats for 28 days. Administration of the aqueous leaf extract caused a statistically significant reduction...

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Chemoprotective Potentials of Ocimum gratissimum in Diesel Petroleum induced Hepatotoxicity in Albino Wistar Rats

This study evaluated the effect of diesel petroleum intoxication in rats and the ability of phytochemicals and antioxidant content of Ocimum gratissimum to ameliorate such toxicity. Toxicity in rat was induced by administering 4 ml/kg body weight of diesel in the test rats except control. The intoxication and treatment with 20 % O. gratissimum supplemented diet was for 7 days. Serum liver funct...

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The effect of date aqua extract and melatonin on diabetic neuropathy in STZ-induced diabetic rats

Introduction: Diabetes mellitus is often associated with chronic neuropathy, a condition which is due to the disturbance in the function of peripheral nervous system. Studying the effects of antioxidants in relieving neuropathy is of a great clinical importance. The aim of this study was to compare the effect of aqua extract of date and Melatonin in preventing neuropathic hyperalgesia in Strept...

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Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl4-Induced Acute Liver Injury

Ocimum gratissimum (OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl(4)) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected ...

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Ethanol-induced hepatotoxicity in male wistar rats: Effects of aqueous leaf extract of Ocimum gratissimum

Ocimum gratissimum leaf is commonly consumed as a spice and sometimes used in folklore medicine in Nigeria and other parts of the world. It has been reported to be rich in natural antioxidants such as flavonoids. The present study sought to evaluate the protective effects of its orally administered aqueous extract (0.2g/kg bwt/day and 0.4g/kg bwt/day for 35 days) on ethanol–induced oxidative st...

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ژورنال

عنوان ژورنال: International Journal of Applied and Basic Medical Research

سال: 2015

ISSN: 2229-516X

DOI: 10.4103/2229-516x.149242